How to: Delete a Worksheet
This example demonstrates how to remove a worksheet from a workbook by calling the WorksheetCollection.Remove or WorksheetCollection.RemoveAt method of the WorksheetCollection object that is accessed via the Workbook.Worksheets property.
// Delete the "Sheet2" worksheet from the workbook.
workbook.Worksheets.Remove(workbook.Worksheets["Sheet2"]);
// Delete the first worksheet from the workbook.
workbook.Worksheets.RemoveAt(0);